prikaz prve stranice dokumenta Evaluation of PD-L1 Expression in Colorectal Carcinomas by Comparing Scoring Methods and Their Significance in Relation to Clinicopathologic Parameters
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Scientific paper - Original scientific paper
Evaluation of PD-L1 Expression in Colorectal Carcinomas by Comparing Scoring Methods and Their Significance in Relation to Clinicopathologic Parameters
Diagnostics, 14 (2024), 10; 1-15. https://doi.org/10.3390/diagnostics14101007
Frančina, Mirela; Mikuš, Mislav; Mamić, Marin; Jovanović, Tihomir; Ćorić, Mario; Lovrić, Božica; Vukoja, Ivan; Zukanović, Goran; Matković, Kristijan; Rajc, Jasmina; Slišurić, Ferdinand; Jurić Marelja, Mateja; Augustin, Goran; Tomaš, Ilijan

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Frančina, M., Mikuš, M., Mamić, M., Jovanović, T., Ćorić, M., Lovrić, B. ... Tomaš, I. (2024). Evaluation of PD-L1 Expression in Colorectal Carcinomas by Comparing Scoring Methods and Their Significance in Relation to Clinicopathologic Parameters. Diagnostics, 14. (10), 1-15. doi: 10.3390/diagnostics14101007

Frančina, Mirela, et al. "Evaluation of PD-L1 Expression in Colorectal Carcinomas by Comparing Scoring Methods and Their Significance in Relation to Clinicopathologic Parameters." Diagnostics, vol. 14, no. 10, 2024, pp. 1-15. https://doi.org/10.3390/diagnostics14101007

Frančina, Mirela, Mislav Mikuš, Marin Mamić, Tihomir Jovanović, Mario Ćorić, Božica Lovrić, Ivan Vukoja, et al. "Evaluation of PD-L1 Expression in Colorectal Carcinomas by Comparing Scoring Methods and Their Significance in Relation to Clinicopathologic Parameters." Diagnostics 14, no. 10 (2024): 1-15. https://doi.org/10.3390/diagnostics14101007

Frančina, M., et al. (2024) 'Evaluation of PD-L1 Expression in Colorectal Carcinomas by Comparing Scoring Methods and Their Significance in Relation to Clinicopathologic Parameters', Diagnostics, 14(10), pp. 1-15. doi: 10.3390/diagnostics14101007

Frančina M, Mikuš M, Mamić M, Jovanović T, Ćorić M, Lovrić B, and sur.. Evaluation of PD-L1 Expression in Colorectal Carcinomas by Comparing Scoring Methods and Their Significance in Relation to Clinicopathologic Parameters. Diagnostics [Internet]. 2024 [cited 2024 November 18];14(10):1-15. doi: 10.3390/diagnostics14101007

M. Frančina, et al., "Evaluation of PD-L1 Expression in Colorectal Carcinomas by Comparing Scoring Methods and Their Significance in Relation to Clinicopathologic Parameters", Diagnostics, vol. 14, no. 10, pp. 1-15, 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:267:940779. [Accessed: 18 November 2024]

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Title (english)Evaluation of PD-L1 Expression in Colorectal Carcinomas by Comparing Scoring Methods and Their Significance in Relation to Clinicopathologic Parameters
AuthorMirela Frančina
AuthorMislav Mikuš
AuthorMarin Mamić
AuthorTihomir Jovanović
AuthorMario Ćorić
AuthorBožica Lovrić
AuthorIvan Vukoja
AuthorGoran Zukanović
AuthorKristijan Matković
AuthorJasmina Rajc
AuthorFerdinand Slišurić
AuthorMateja Jurić Marelja
AuthorGoran Augustin
AuthorIlijan Tomaš
Author's institution(Clinical hospital center Osijek)
Author's institution(Zagreb University Hispital Center)
Author's institution(County General Hospital Požega)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
Background: This study aims to evaluate PD-L1 expression in colorectal carcinomas (CRCs) by using the tumor proportion score (TPS) and the combined positive score (CPS), and to investigate whether there is a correlation with clinicopathologic features. Methods: A cross-sectional study was conducted that included samples from patients with colorectal adenocarcinoma treated with colon resection and rectal resection after neoadjuvant radio- and chemotherapy at the Department of Abdominal Surgery at Požega Hospital in the period from 2017 to 2022. The study included 102 tumor tissue samples from patients after resection and the pathohistological diagnosis of adenocarcinoma. Results: In our study, the PD-L1 positivity rate after the TPS was 42 (41%) samples, and after the CPS, 97 (95%) of them (p < 0.001). The positive expression of PD-L1 in tumor cells using the TPS method showed a statistically significant association with adenocarcinoma (TPS ≥ 10–50% and ≥50%). There were significantly more that were moderately differentiated, with TPS ≥ 50%, and those poorly differentiated had values ≥ 10–50%. There were significantly more patients with a status of more than one positive lymph node with TPS values ≥ 10–50%. Patients without metastases in the lymph nodes are significantly more likely to have CPS values > 50%, compared with other lymph node statuses. Conclusions: These results suggest that the total number of PD-L1-expressing cells, including tumor and immune cells, is a more sensitive biomarker than the number of PD-L1-expressing tumor cells alone in CRC.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleDiagnostics
Numberingvol. 14, no. 10, pp. 1-15
p-ISSN2075-4418
DOIhttps://doi.org/10.3390/diagnostics14101007
URN:NBNurn:nbn:hr:267:940779
Publication2024
Document URLhttps://www.mdpi.com/2075-4418/14/10/1007
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-05-22 06:15:58