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Evaluation of PD-L1 Expression in Colorectal Carcinomas by Comparing Scoring Methods and Their Significance in Relation to Clinicopathologic Parameters
Diagnostics, 14 (2024), 10; 1-15. https://doi.org/10.3390/diagnostics14101007
Frančina, Mirela; Mikuš, Mislav; Mamić, Marin; Jovanović, Tihomir; Ćorić, Mario; Lovrić, Božica; Vukoja, Ivan; Zukanović, Goran; Matković, Kristijan; Rajc, Jasmina; Slišurić, Ferdinand; Jurić Marelja, Mateja; Augustin, Goran; Tomaš, Ilijan

Citirajte ovaj rad

Frančina, M., Mikuš, M., Mamić, M., Jovanović, T., Ćorić, M., Lovrić, B. ... Tomaš, I. (2024). Evaluation of PD-L1 Expression in Colorectal Carcinomas by Comparing Scoring Methods and Their Significance in Relation to Clinicopathologic Parameters. Diagnostics, 14. (10), 1-15. doi: 10.3390/diagnostics14101007

Frančina, Mirela, et al. "Evaluation of PD-L1 Expression in Colorectal Carcinomas by Comparing Scoring Methods and Their Significance in Relation to Clinicopathologic Parameters." Diagnostics, vol. 14, br. 10, 2024, str. 1-15. https://doi.org/10.3390/diagnostics14101007

Frančina, Mirela, Mislav Mikuš, Marin Mamić, Tihomir Jovanović, Mario Ćorić, Božica Lovrić, Ivan Vukoja, et al. "Evaluation of PD-L1 Expression in Colorectal Carcinomas by Comparing Scoring Methods and Their Significance in Relation to Clinicopathologic Parameters." Diagnostics 14, br. 10 (2024): 1-15. https://doi.org/10.3390/diagnostics14101007

Frančina, M., et al. (2024) 'Evaluation of PD-L1 Expression in Colorectal Carcinomas by Comparing Scoring Methods and Their Significance in Relation to Clinicopathologic Parameters', Diagnostics, 14(10), str. 1-15. doi: 10.3390/diagnostics14101007

Frančina M, Mikuš M, Mamić M, Jovanović T, Ćorić M, Lovrić B, i sur.. Evaluation of PD-L1 Expression in Colorectal Carcinomas by Comparing Scoring Methods and Their Significance in Relation to Clinicopathologic Parameters. Diagnostics [Internet]. 2024. [pristupljeno 27.10.2024.];14(10):1-15. doi: 10.3390/diagnostics14101007

M. Frančina, et al., "Evaluation of PD-L1 Expression in Colorectal Carcinomas by Comparing Scoring Methods and Their Significance in Relation to Clinicopathologic Parameters", Diagnostics, vol. 14, br. 10, str. 1-15, 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:267:940779. [Citirano: 27.10.2024.]

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Podaci o radu
Naslov (engleski)Evaluation of PD-L1 Expression in Colorectal Carcinomas by Comparing Scoring Methods and Their Significance in Relation to Clinicopathologic Parameters
AutorMirela Frančina
AutorMislav Mikuš
AutorMarin Mamić
AutorTihomir Jovanović
AutorMario Ćorić
AutorBožica Lovrić
AutorIvan Vukoja
AutorGoran Zukanović
AutorKristijan Matković
AutorJasmina Rajc
AutorFerdinand Slišurić
AutorMateja Jurić Marelja
AutorGoran Augustin
AutorIlijan Tomaš
Autorova ustanova(Klinički bolnički centar Osijek)
Autorova ustanova(Klinički bolnički centar Zagreb)
Autorova ustanova(Opća županijska bolnica Požega)
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
Background: This study aims to evaluate PD-L1 expression in colorectal carcinomas (CRCs) by using the tumor proportion score (TPS) and the combined positive score (CPS), and to investigate whether there is a correlation with clinicopathologic features. Methods: A cross-sectional study was conducted that included samples from patients with colorectal adenocarcinoma treated with colon resection and rectal resection after neoadjuvant radio- and chemotherapy at the Department of Abdominal Surgery at Požega Hospital in the period from 2017 to 2022. The study included 102 tumor tissue samples from patients after resection and the pathohistological diagnosis of adenocarcinoma. Results: In our study, the PD-L1 positivity rate after the TPS was 42 (41%) samples, and after the CPS, 97 (95%) of them (p < 0.001). The positive expression of PD-L1 in tumor cells using the TPS method showed a statistically significant association with adenocarcinoma (TPS ≥ 10–50% and ≥50%). There were significantly more that were moderately differentiated, with TPS ≥ 50%, and those poorly differentiated had values ≥ 10–50%. There were significantly more patients with a status of more than one positive lymph node with TPS values ≥ 10–50%. Patients without metastases in the lymph nodes are significantly more likely to have CPS values > 50%, compared with other lymph node statuses. Conclusions: These results suggest that the total number of PD-L1-expressing cells, including tumor and immune cells, is a more sensitive biomarker than the number of PD-L1-expressing tumor cells alone in CRC.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaDiagnostics
Brojčani podacivol. 14, br. 10, str. 1-15
p-ISSN2075-4418
DOIhttps://doi.org/10.3390/diagnostics14101007
URN:NBNurn:nbn:hr:267:940779
Datum objave publikacije2024
URL dokumentahttps://www.mdpi.com/2075-4418/14/10/1007
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-05-22 06:15:58